Products with biofunctional coating

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G - Physics

01

N

G01N 33/543 (2006.01)

Patent

CA 2427033

The invention relates to products comprising a solid surface, a multilayer system of at least two covalently interconnected layers of a polymeric material covalently attached to said surface, and a biofunctional layer covalently attached to said multilayer system. The biofunctional layer may comprise a bioactive ingredient to make the product useful for numerous applications, such as biosensors, implants, sample containers, affinity sensor arrays and affinity chromatography media. The invention also relates to methods for making such products. The use of a multilayer system of organic polymers allows to obtain almost identical biofunctional surfaces on very different substrates and provides a more complete shielding of the original surface of the substrate which reduces non-specific absorption of biomolecules.

L'invention concerne des produits comportant une surface solide, un système multicouches d'au moins deux couches interconnectées de manière covalente, d'un matériau polymérique de manière covalente fixé à ladite surface et d'une couche biofonctionnelle fixée de manière covalente audit système multicouches. La couche biofonctionnelle peut comprendre un ingrédient bioactif afin de fabriquer le produit utile à de nombreuses applications, tels que des biocapteurs, des implants, des conteneurs d'échantillon, des ensembles de capteur d'affinité et un média de chromatographie d'affinité. L'invention concerne également des procédés de fabrication de tels produits. L'utilisation d'un système multicouches de polymères organiques permet d'obtenir des surfaces presque biofonctionnelles identiques sur des substrats de nature très différente et offre une protection plus complète de la surface d'origine du substrat qui réduit l'absorption non spécifique de biomolécules.

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