C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/10 (2006.01) A61K 31/435 (2006.01) A61K 31/499 (2006.01) C07D 401/02 (2006.01)
Patent
CA 2580020
The present invention is directed to compounds of Formula (I): where variables A1, A2, B, J, K, m, n, R4, R5a, R5b, R5c and X are as defined herein useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
La présente invention concerne des composés représentés par la formule (I): dans cette formule, les variables A1, A2, B, J, K, m, n, R4, R5a, R5b, R5c et X sont telles que définies dans la description; ces composés sont utilisés en tant qu'antagonistes des récepteurs CGRP et ils sont utilises pour traiter ou prévenir des maladies impliquant la CGRP, telles que la céphalée, la migraine et la céphalée de Horton. Cette invention concerne également des compositions pharmaceutiques comprenant ces composés ainsi que l'utilisation de ces composés pour prévenir ou traiter des maladies dans lesquelles la CGRP est impliquée.
Bell Ian M.
Stump Craig A.
Theberge Cory R.
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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