Botulinum neurotoxin a protein receptor and uses thereof

Details Botulinum neurotoxin a protein receptor and uses thereof Botulinum neurotoxin a protein receptor and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 14/705 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07K 16/28 (2006.01) C12N 15/12 (2006.01) G01N 33/566 (2006.01) C07K 14/33 (2006.01) C12N 9/52 (2006.01)

Patent

CA 2627457

The invention relates to a polypeptide comprising an amino acid sequence, at least 70 percent of which are identical to the amino acid sequence of the synaptic vesicle glycoprotein of homo sapiens. Said polypeptide binds the HC fragment of botulinum neurotoxin A provided that the polypeptide is not the synaptic vesicle glycoprotein 2C of homo sapiens.

L'invention concerne un polypeptide composé d'une séquence d'acide aminé, laquelle est pour au moins 70 % identique à la séquence d'acide aminé de la glycoprotéine 2C de la vésicule synaptique de Homo sapiens. Le polypeptide lie le fragment HC-de la neurotoxine A de Botulinus, à condition que le polypeptide de soit pas la glycoprotéine 2C de la vésicule synaptique de Homo sapiens.

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