Peptide vaccines against group a streptococci

Details Peptide vaccines against group a streptococci Peptide vaccines against group a streptococci

A - Human Necessities

61

K

A61K 39/02 (2006.01) C07H 21/04 (2006.01) C07K 14/31 (2006.01) C07K 14/315 (2006.01) C12N 1/21 (2006.01) C12N 15/74 (2006.01) C12P 21/02 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2447599

This invention, in one aspect, relates to synthetic immunoreactive peptides. These peptides are approximately 20-25 amino acids in length which are portions of the N termini of the M proteins of the most prevalent United States (U.S.) Group A Streptococcus (GAS) serotypes. At least some of the synthetic peptides can be recognized by M type-specific antibodies and are capable of eliciting functional opsonic antibodies and/or anti-attachment antibodies without eliciting tissue cross- reactive antibodies. In another aspect, it relates to compositions or vaccines comprising these synthetic serotype-specific peptides, including polypeptides and proteins. The invention may also be isolated antibodies which are raised in response to the peptides, compositions or vaccines. The invention further relates to kits for using the peptides, compositions, or antibodies. In still further aspects, the invention also relates to methods for using the peptides, compositions, vaccines, or antibodies and methods for tailoring vaccines.

Un aspect de cette invention concerne des peptides immunoréactifs de synthèse. Ces peptides présentent une longueur d'environ 20-25 acide aminés qui sont des parties des séquences N-terminales des protéines M exprimées par les sérotypes de streptocoques du groupe A (SGA) les plus courants aux Etats Unis. Une partie au moins de ces peptides de synthèse peuvent être reconnus par des anticorps spécifiques du type M et suscitent la production d'anticorps opsoniques fonctionnels et/ou d'anticorps empêchant la fixation sans produire d'anticorps à réaction croisée tissulaire. Un autre aspect de cette invention concerne des compositions ou des vaccins comprenant les peptides spécifiques des sérotypes, ainsi que des polypeptides et des protéines. Cette invention concerne également des anticorps isolés qui sont produits en réponse à ces peptides, compositions ou vaccins. Elle concerne en outre des ensembles de matériel permettant l'utilisation de ces peptides, compositions ou anticorps. Dans des aspects encore différents, l'invention concerne des procédés d'utilisation de ces peptides, compositions, vaccins ou anticorps et des procédés permettant la préparation de vaccins spécifiques.

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