Substituted bicyclic heteroaroylguanidines, a process for...

Details Substituted bicyclic heteroaroylguanidines, a process for... Substituted bicyclic heteroaroylguanidines, a process for...

C - Chemistry, Metallurgy

07

D

C07D 215/48 (2006.01) A61K 31/165 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) C07C 279/22 (2006.01) C07D 215/54 (2006.01) C07D 217/26 (2006.01) C07D 401/00 (2006.01) C07D 403/00 (2006.01) C07D 405/00 (2006.01) C07D 409/00 (2006.01) C07D 413/00 (2006.01) C07D 417/00 (2006.01)

Patent

CA 2148666

Compounds of the formula I Image I where T, U, V, W, X, Y and Z are, independently of each other, nitrogen or carbon, R(1) and R(2) are H, Hal, (perfluoro)-alkyl, OR(8), NR(8)R(9) or C(=O) N=C(NH2)2, R(3), R(4), R(5), R(6) and R(7) are H, Hal-CN, Xk-(CH2)p- (CqF2q=1). R (10a) -SObm, R (10b) R(10c)N-CO, R(11)-CO- or R(12)R(13)N-SO2-; or R(3), R(4), R(5), R(6) and R(7) are alk(en)yl or heteroaryl; or R(3), R(4), R(5), R(6) and R(7) are Image or Image or Image or R(3), R(4), R(5), R(6) and R(7) are SR(29), -OR(30), -NR(31)R(32) or -CR(33)R(34)R(35); or R(3), R(4), R(5), R(6) and R(7) are Image . Image or Image or R(3), R(4), R(5), R(6) and R(7) are R(46)X(1)-; or R(3), R(4), R(5), R(6) and R(7) are -SR(64), -OR(65), -NHR(66), -NR(67)R(68), -CHR(69)R(70), -CR(54)R(55)OH, -CCR(56), -CR(58)=CR(57) or -[CR(59)R(60)]u-CO- [CR(61)R(62)]v-R(63); or R(3), R(4), R(5), R(6) and R(7) are R(76)-NH-SO2-; or R(3), R(4), R(5), R(6) and R(7) are NR(84a)R(85), OR(84b), SR(84c) or -CnH2n-R(84d) are described, as are the pharmaceutically tolerated salts thereof. A process for their preparation, and their use as medicines in cardiovascular diseases, are also described.

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