C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 513/04 (2006.01) A61K 31/5415 (2006.01) A61K 31/549 (2006.01) A61P 25/00 (2006.01) C07D 209/00 (2006.01) C07D 279/02 (2006.01) C07D 285/00 (2006.01)
Patent
CA 2471263
The invention concerns compounds of formula (I), wherein: R¿1? represents an aryl or heteroaryl; R¿2? represents hydrogen, halogen or a hydroxy; A represents CR¿4?R¿5? or NR¿4?; R¿3? represents hydrogen, alkyl or cycloalkyl; R¿4? represents hydrogen or an alkyl; or A represents a nitrogen and forms with adjacent -CHR¿3?- the cycle (a), wherein m represents 1, 2 or 3; R¿5? represents hydrogen or halogen; their isomers and addition salts. Said compounds are useful as AMPA modulators.
Composés de Formule (I) dans laquelle : R1 représente un aryle ou hétéroaryle, R2 représente un hydrogène, halogène ou un hydroxy, A représente CR4R5 ou NR4, R3 représente un hydrogène, alkyle ou cycloalkyle, R4 représente un hydrogène ou un alkyle, ou bien A représente un azote et forme avec -CHR3- adjacent le cycle dans lequel m représente 1, 2 ou 3, R5 représente un hydrogène ou halogène, leurs isomères ainsi que leurs sels d~addition. Médicaments comme modulateurs AMPA.
Cordi Alex
Desos Patrice
Lestage Pierre
Les Laboratoires Servier
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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