Methods and compositions using thalidomide for the treatment...

Details Methods and compositions using thalidomide for the treatment... Methods and compositions using thalidomide for the treatment...

A - Human Necessities

61

K

A61K 31/445 (2006.01)

Patent

CA 2551518

Methods of treating, preventing and/or managing central nervous system disorders, such as Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig~s Disease) and related syndromes are disclosed. Specific methods encompass the administration of thalidomide, or a pharmaceutically acceptable salt, solvate, hydrate, or stereoisomer thereof, alone or in combination with a second active ingredient. Pharmaceutical compositions, single unit dosage form, and kits suitable for use in methods of the invention are also disclosed.

L'invention concerne des procédés de traitement, de prévention et/ou de prise en charge de troubles du système nerveux central tels que la sclérose latérale amyotrophique (SLA ou maladie de Lou Gehrig) et de syndromes associés. Des procédés spécifiques consistent à administrer la thalidomide ou un sel, solvate, hydrate ou stéréoisomère pharmaceutiquement acceptable de celle-ci, seule ou en combinaison avec un deuxième agent actif. L'invention concerne également des compositions pharmaceutiques, des formes de dosage unitaires et des ensembles destinés à être employés dans des procédés selon l'invention.

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