C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/005 (2006.01) A61K 39/12 (2006.01) C07K 14/045 (2006.01) C07K 16/08 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2401638
The invention provides a plurality of peptides (and immunologically functional variants thereof) which are immunogenic epitopes recognized by CD8+ class I MHC restricted cytotoxic T-lymphocytes of patients harboring latent human cytomegalovirus (HCMV) infection. The peptides are capable of activating CTLs and CTLps in the absence of active viral replication, and thus are useful for eliciting a cellular immune response against HCMV by normal and immunodeficient subjects. Peptide and lipopeptide vaccines, with and without adjuvants, also are disclosed. Cellular vaccines comprising the peptides form a further embodiment of this invention.
L'invention concerne plusieurs peptides (ainsi que leurs variants immunologiquement fonctionnels) constituant des épitopes immunogènes reconnus par les lymphocytes T cytotoxiques CD8 + de classe I à restriction au CMH chez les patients couvant une infection latente par le cytomégalovirus (HCMV). Ces peptides, qui sont capables d'activer les CTL et les CTLp en absence de réplication virale active, conviennent pour éliciter une réponse immunitaire cellulaire contre le HCMV de la part de sujets normaux et de sujets immunodéficients. L'invention concerne également des vaccins peptidiques et lipopeptidiques, avec ou sans adjuvants. Dans une autre forme de réalisation, l'invention concerne des vaccins cellulaires renfermant lesdits peptides.
City Of Hope
Osler Hoskin & Harcourt Llp
LandOfFree
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