Process for the synthesis of nucleoside analogs

Details Process for the synthesis of nucleoside analogs Process for the synthesis of nucleoside analogs

C - Chemistry, Metallurgy

07

H

C07H 19/14 (2006.01) C07H 19/04 (2006.01) C07H 19/06 (2006.01) C07H 19/16 (2006.01) C07H 19/23 (2006.01)

Patent

CA 2307951

The present invention relates to an improved method for synthesizing nucleosides with a low .alpha.:.beta. anomeric ratio. The method comprises coupling a protected furanosyl halide and an appropriately protected heterocycle in the presence of a nucleophilic polar solvent and a strong base.

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