C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/18 (2006.01) A61K 31/435 (2006.01) C07D 221/00 (2006.01)
Patent
CA 2317570
A compound of formula (I), wherein X' is nitrogen or carbon bonded to a substituent species characterized as having a sigma m value greater than 0, less than 0 or 0; X is nitrogen or carbon bonded to a substituent species characterized as having a sigma m value equal to 0; A, A' and A" are individually substituent species characterized as having a sigma m value greater than 0, less than 0 or 0; Z' is a substituent other than hydrogen; j is an integer from 0 to 5; and the wavy line in the structure indicates that the compound can exist in the form of an enantiomer or a diasteromer; Z" is hydrogen or a substituent other than hydrogen; Y is C=O, C(OH)R' or C-A, where R' is hydrogen or lower alkyl is provided.
L'invention porte sur un composé de formule (I) dans laquelle: X' est N ou C lié à un substituant présentant un .SIGMA.m supérieur, inférieur, ou égal à zéro; X est N ou C lié à un substituant présentant un .SIGMA.m égal à zéro; A, A' et A'' sont individuellement des substituants présentant un .SIGMA.m supérieur, inférieur, ou égal à zéro; Z' est un substituant autre que H; j est un entier de 0 à 5; la ligne brisée de la structure indique que le composé existe sous forme d'énantiomère ou de diastéromère; Z'' est H ou un substituant autre que H; Y est C=O, C(OH)R' ou C-A, R' étant H ou alkyle inférieur.
Crooks Peter Anthony
Deo Niranjan Madhukar
R.j. Reynolds Tobacco Company
Robic
Targacept Inc.
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