Renoprotection by growth hormone-releasing hormone and agonists

Details Renoprotection by growth hormone-releasing hormone and agonists Renoprotection by growth hormone-releasing hormone and agonists

A - Human Necessities

61

K

A61K 38/27 (2006.01) A61P 39/00 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2605036

In the present study, regulation of renal and pituitary GHRH-R mRNA levels was examined using in vivo models of NaCl or water homeostasis disruption. The presence of a unique GHRH/GHRH-R system in Henle's loop ascending thin limb cell and the specific regulation of GHRH-R mRNA levels and GHRH sensitivity in a situation of hyperosmotic stress, together with the strong effect of GHRH on mitochondrial and nuclear DNA repair/synthesis, indicate a role for GHRH in renoprotection. GHRH appears to be involved in adaptive processes related to DNA repair and/or synthesis thereby protecting ascending limb cell function in subjects with renal vulnerability (aging, diabetes) and were a health event could lead to a production of oxidative stress (antibiotic toxicity, cancer chemotherapeutic agent toxicity, infection, inflammation, ischemia ) and renal failure.

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