Substituted urea compounds and their preparation and use

Details Substituted urea compounds and their preparation and use Substituted urea compounds and their preparation and use

C - Chemistry, Metallurgy

07

D

C07D 451/14 (2006.01) A61K 31/435 (2006.01) C07D 451/04 (2006.01) C07D 453/02 (2006.01) C07D 453/06 (2006.01) C07D 471/08 (2006.01) C07D 487/08 (2006.01)

Patent

CA 2074803

2074803 9112254 PCTABS00006 New substituted urea compounds of formula (I), or a pharmaceutically acceptable salt thereof, wherein A is (.alpha.), (.beta.) or (.psi.), wherein R3 is an oxadiazol, substituted with C1-8-alkyl, C2-8-alkenyl, C2-8 alkynyl, C3-7 cycloalkyl, benzyl, phenyl, C1-6-alkoxy, C1-6-alkylthio, amino or alkylamino; R2 is -H or lower alkyl; X is O or S; and R1 is a group of formula (II), (III), (IV) or (V), where n is 2 or 3, p is 1 or 2, q is 1 to 3, r is 1-3 and R4 and R5 are H, C1-7 alkyl or C3-6 cycloalkyl; and N-oxides thereof. The compounds are useful in pharmaceutical preparations for treating psychotic disorders, nausea and vomiting.

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