Compositions comprising a mast cell degranulation-blocking...

A - Human Necessities – 61 – K

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A61K 38/09 (2006.01) A61K 31/00 (2006.01) A61K 31/13 (2006.01) A61K 31/135 (2006.01) A61K 31/19 (2006.01) A61K 31/35 (2006.01) A61K 31/415 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) A61K 31/55 (2006.01) A61K 31/565 (2006.01) A61K 31/575 (2006.01)

Patent

CA 2183069

A method for treating endogenous, painful gastrointestinal conditions of non-inflammatory, non-ulcerative origin, such as abdominal migraine and irritable bowel syndrome, entails administering a pharmaceutically effective amount of a mast cell degranulation-blocking agent, e.g. a naturally occurring polyamine, a heterocyclic histamine-1 receptor antagonist, a histamine-3 receptor agonist or an anti-female sex hormone.

Procédé de traitement d'affections gastro-intestinales endogènes douloureuses d'origine non inflammatoire et non ulcéreuse, telles que migraine accompagnée de symptômes au niveau abdominal ou côlon irritable, impliquant l'administration en quantité efficace sur le plan pharmacologique d'un inhibiteur de la dégranulation opérée par les mastocytes, par exemple d'une polyamine d'origine naturelle, d'un antagoniste hétérocyclique des récepteurs d'histamine-1, d'un agoniste des récepteurs d'histamine-3 ou d'une anti-hormone sexuelle femelle.

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