Use of iap inhibitors for the treatment of acute myeloid...

Details Use of iap inhibitors for the treatment of acute myeloid... Use of iap inhibitors for the treatment of acute myeloid...

A - Human Necessities

61

K

A61K 31/437 (2006.01) A61P 35/02 (2006.01)

Patent

CA 2670270

The present invention relates to methods of treating hematological malignancies, including acute myeloid leukemia (AML), comprising the use of compounds that inhibit the binding of the Smac protein to IAPs ("IAP inhibitor"). The present invention also relates to the use of IAP inhibitors for the preparation of a medicament to treat hematological malignancies, including AML..

La présente invention concerne des méthodes de traitement de malignités hématologiques, y compris la leucémie aiguë myéloïde (LAM), consistant à utiliser des composés qui inhibent la fixation de la protéine Smac aux protéines IAP ("inhibiteur des IAP"). La présente invention concerne également l'utilisation d'inhibiteurs des IAP pour la préparation d'un médicament destiné au traitement de malignités hématologiques, y compris la LAM.

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