Polymeric thiol-linked prodrugs

Details Polymeric thiol-linked prodrugs Polymeric thiol-linked prodrugs

C - Chemistry, Metallurgy

07

H

C07H 19/16 (2006.01) A61K 9/14 (2006.01) A61K 31/74 (2006.01) A61K 39/395 (2006.01) A61K 39/40 (2006.01) A61K 39/42 (2006.01) A61K 39/44 (2006.01) A61K 47/48 (2006.01) C07D 473/38 (2006.01)

Patent

CA 2465206

Thiol-linked polymeric prodrugs and methods of making and using the same are disclosed. The use of a sulfhydryl bond as the basic link for linking the polymer to the drug allows a prodrug to be formed which takes advantage of plasma enzymes in vivo. A preferred conjugate is. Methods of preparing and treatment are also disclosed.

L'utilisation d'une liaison sulfhydryle servant de liaison de base ~ la liaison du polym­re avec le prom~dicament permet d'obtenir un prom~dicament qui tire profit des enzymes du plasma in vivo. De pr~f~rence, le conjugu~ est repr~sent~ sous forme. Font ~galement l'objet de cette invention des proc~d~s de pr~paration et de traitement.

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