A human t-cell receptor of the g-protein coupled receptor...

Details A human t-cell receptor of the g-protein coupled receptor... A human t-cell receptor of the g-protein coupled receptor...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07K 14/705 (2006.01) C07K 14/725 (2006.01) C07K 16/28 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2159813

This invention relates to nucleotide sequences coding for a human T-cell receptor, to recombinant DNA comprising such nucleotide sequences, vectors comprising such recombinant DNA, and transformed cells and transgenic animals comprising such a nucleotide sequence. This invention further relates to polypeptides which function as a receptor in human T-cells, to antibodies thereto and to ligands which bind to said polypeptide. This invention also relates to an assay for the ability of an agent to act as an agonist or antagonist of said T-cell receptor and to antisense sequences to said nucleotide sequences.

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