Synthesis of (s)-3-(2-thienylthio) butyric acid and analogs

Details Synthesis of (s)-3-(2-thienylthio) butyric acid and analogs Synthesis of (s)-3-(2-thienylthio) butyric acid and analogs

C - Chemistry, Metallurgy

07

D

C07D 333/34 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2218654

This invention is concerned with an improved process for the synthesis of and intermediate en route to 5,6-dihydro-(s)-4-(ethylamino)-(s)-6-methyl-4h- thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide and related compounds. The instant process reduces the reaction time for the synthesis of the key intermediate from 3 to 4 days to from about 2 to about 4 hours while retaining the high enantiomeric purity of the product.

Procédé amélioré de synthèse d'un intermédiaire en vue de la préparation de 5,6-dihydro-(s)-4-(éthylamino)-(s)-6-méthyl-4h-thiéno(2,3-b)thiopyrane-2-sulfonamide 7,7-dioxyde et de composés associés. Ce procédé réduit le temps de réaction pour la synthèse de cet intermédiaire essentiel, le faisant passer de 3 à 4 jours à 2 à 4 heures environ, tout en préservant la pureté énantiomérique élevée du produit.

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