Microparticles for delivery of nucleic acid

Details Microparticles for delivery of nucleic acid Microparticles for delivery of nucleic acid

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 9/16 (2006.01) C12N 15/11 (2006.01) C12N 15/31 (2006.01) C12N 15/33 (2006.01) C12N 15/87 (2006.01)

Patent

CA 2278450

Disclosed is a preparation of microparticles made up of a polymeric matrix and a nucleic acid expression vector. The polymeric matrix includes one or more synthetic polymers having a solubility in water of less than about 1 mg/l. At least 90 % of the microparticles have a diameter less than about 100 microns. The nucleic acid is either RNA, at least 50 % of which is in the form of closed circles, or circular DNA plasmid molecules, at least 50 % of which are supercoiled.

L'invention porte sur une préparation de microparticules constituées d'une matrice polymère, et sur un vecteur d'expression de l'acide nucléique. La matrice polymère comprend un ou plusieurs polymères synthétiques dont la solubilité dans l'eau est inférieure à environ 1 mg/l. Au moins 90 % des microparticules ont un diamètre inférieur à environ 100 microns. L'acide nucléique est soit l'ARN dont au moins 50 % se présente sous la forme de cercles fermés, soit des molécules de plasmide d'ADN dont au moins 50 % sont enroulés en superhélices.

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