Imidazole compounds, their preparation and use

Details Imidazole compounds, their preparation and use Imidazole compounds, their preparation and use

C - Chemistry, Metallurgy

07

D

C07D 233/24 (2006.01) C07D 401/06 (2006.01) C07D 403/06 (2006.01) C07D 405/06 (2006.01)

Patent

CA 2069144

The present patent application discloses compounds of the formula Image wherein R1 is C1-C10-saturated alkyl which may be branched; G1-10- unsaturated alkyl; or CHR''' Image wherein R''' is H or - (C=O) Image ; ' R2 is phenyl which may be substituted one or more times with halogen, CF3, C1-6-alkoxy, NO2, CO2-C1-6-alkyl, methyl; benzyl which may be substituted one or more times with halogen, CF3, C1-6-alkoxy, NO2, CO2-C1-6-alkyl, methyl or cyclohexyl; R3 phenyl which may be substituted one or more times with halogen, CF3, C1-6-alkoxy, NO2, CO2-C1-6-alkyl, methyl; naphthyl which may be substituted one or more times with halogen, CF3, C1-6-alkoxy, NO2, CO2-C1-6-alkyl, methyl; C1-6 unsaturated alkyl; R4 is H, C1-6-alkyl, or benzyl; R5 is H, or C1-6-alkyl; R' and R" are each hydrogen; or a pharmaceutically-acceptable addition salt thereof. The compounds are useful as pharmaceuticals, for example in the -treatment of Ca overload in brain cells.

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