C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/12 (2006.01) C12Q 1/48 (2006.01) G01N 33/483 (2006.01)
Patent
CA 2226963
The invention relates to human ZAP-70, and in particular, to the region of ZAP- 70 containing the tandem Src homology-2 ("SH2") domains, to crystalline forms thereof, liganded or unliganded, which are particularly useful for the determination of the three-dimensional structure of the protein. The three- dimensional structure of the tandem SH2 region of ZAP provides information useful for the design of pharmaceutical compositions which inhibit the biological function of ZAP and other members of the ZAP family of SH2 domain- containing proteins, particularly those biological functions mediated by molecular interactions involving one or both SH2 domains.
L'invention concerne la ZAP-70 de l'homme et, en particulier, la région de ZAP-70 contenant les domaines tandem d'homologie-2 de Src ("SH2"), ses formes cristallines, à ligand ou sans ligand, qui sont particulièrement utiles pour déterminer la structure tridimensionnelle de la protéine. La structure tridimensionnelle de la région tandem de SH2 de la ZAP fournit des informations utiles à la conception de compositions pharmaceutiques inhibant la fonction biologique de la ZAP et d'autres membres de la famille ZAP de protéines contenant les domaines de SH2, en particulier les fonctions biologiques induites par des interactions moléculaires impliquant un ou deux domaines de SH2.
Hatada Marcos H.
Holt Dennis A.
Karas Jennifer L.
Laird Ellen R.
Lu Xiaode
Ariad Pharmaceuticals Inc.
Borden Ladner Gervais Llp
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