A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/08 (2006.01) A61P 25/16 (2006.01) A61P 25/28 (2006.01) C07K 16/18 (2006.01)
Patent
CA 2723967
The present invention relates to the use of mimotopes in the treatment of .beta.-Amyloidoses including but not limited to Alzheimer's disease, whereby said mimotopes are able to induce the in vivo formation of antibodies directed to non truncated A.beta.1-40/42, and N-terminally truncated forms A.beta.pE3-40/42, A.beta.3- 40/42, A.beta.11-40/42, A.beta.pE11-40/42 and A.beta.14-40/42 without in-terfering with physiological functions of APP signalling.
La présente invention concerne lutilisation de mimotopes dans le traitement damyloïdoses ß comprenant, de manière non restrictive, la maladie d'Alzheimer, ces mimotopes étant capables dinduire la formation in vivo danticorps dirigés contre Aß1-40/42 non tronqué, et les formes tronquées à lextrémité N-terminale dAßpE3-40/42, dAß3-40/42, dAß11-40/42, dAßpE11-40/42 et dAß14-40/42 sans interférer avec les fonctions physiologiques de la signalisation de lAPP.
Kopinits Edith
Mandler Markus
Santic Radmila
Weninger Harald
Affiris Ag
Gowling Lafleur Henderson Llp
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