Gp120 mutants and biological applications

Details Gp120 mutants and biological applications Gp120 mutants and biological applications

C - Chemistry, Metallurgy

12

N

C12N 15/48 (2006.01) A61K 38/16 (2006.01) C07K 14/16 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2352603

The invention concerns gp120 mutants comprising at least a mutation in a region rich in aromatic amino acids of the helix .alpha.1 and/or the helix .alpha.2 of the gp120. The invention is useful for preparing compounds with inhibiting properties towards gp120.

L'invention vise des mutants de la gp120 comportant au moins une mutation dans une région riche en acides aminés aromatiques de l'hélice .alpha.1 et/ou de l'hélice .alpha.2 de la gp120 (applications à l'élaboration de composés présentant des propriétés inhibitrices vis-à-vis de la gp120).

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