C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 498/04 (2006.01) A61K 31/5383 (2006.01) A61P 35/00 (2006.01) C07D 519/00 (2006.01)
Patent
CA 2571807
The present invention relates to tricyclic pyrazoles according to Formula (I) that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also relates to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
La présente invention concerne des pyrazoles tricycliques selon la formule (I) utiles pour traiter des maladies liées à la prolifération cellulaire, pour traiter des troubles associés à l'activité de la kinésine KSP, et pour inhiber la kinésine KSP. L'invention concerne également des compositions comprenant ces composés, et des méthodes d'utilisation desdits composés pour traiter le cancer chez des mammifères.
Bergman Jeffrey M.
Coleman Paul J.
Fraley Mark E.
Garbaccio Robert M.
Hartman George D.
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
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