Quinazolinones as potassium channel modulators

Details Quinazolinones as potassium channel modulators Quinazolinones as potassium channel modulators

C - Chemistry, Metallurgy

07

D

C07D 239/95 (2006.01) A61K 31/517 (2006.01) A61K 31/519 (2006.01) A61K 31/549 (2006.01) A61P 25/00 (2006.01) C07D 285/24 (2006.01) C07D 401/12 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2505195

Compounds, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels. More particularly, the invention provides quinazolinone, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders (e.g., migraine, ataxia, Parkinson's disease, bipolar disorders, trigeminal neuralgia, spasticity, mood disorders, brain tumors, psychotic disorders, myokymia, seizures, epilepsy, hearing and vision loss, Alzheimer's disease, age-related memory loss, learning deficiencies, anxiety and motor neuron diseases) and as neuroprotective agents (e.g., to prevent stroke and the like) by modulating potassium channels associated with the onset or recurrence of the indicated conditions.

L'invention concerne des composés, des compositions et des procédés utiles dans le traitement de maladies par la modulation du flux ionique du potassium traversant des canaux potassiques dépendant de la tension. Plus précisément, l'invention concerne la quinazolinone, des compositions et des procédés utiles dans le traitement des troubles du système nerveux central ou périphérique (par exemple migraine, ataxie, maladie de Parkinson, troubles bipolaires, névralgie faciale, spasticité, troubles de l'humeur, tumeurs cérébrales, trouble psychotiques, myokymie, crises, épilepsie, perte de l'ouïe et de la vision, maladie d'Alzheimer, perte de mémoire liée à l'âge, déficiences d'apprentissage, anxiété et maladies neuromotrices) et comme agents neuroprotecteurs (par exemple pour prévenir les accidents cérébrovasculaires et analogues) par modulation des canaux potassiques associés à l'apparition ou à la récurrence des états précités.

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