Human protease and use of such protease for pharmaceutical...

Details Human protease and use of such protease for pharmaceutical... Human protease and use of such protease for pharmaceutical...

C - Chemistry, Metallurgy

12

N

C12N 15/57 (2006.01) A61K 38/48 (2006.01) C12N 1/21 (2006.01) C12N 9/54 (2006.01) C12N 9/64 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2325010

The present invention relates to a method of producing novel improved protein mutant which produce low allergenic response in humans compared to the parent of that mutant. Specifically, the present invention comprises neutralizing or reducing the allergenicity of a protein by introducing therein as replacement or modification of an epitope on such protein a sequence from human subtilisin.

L'invention porte sur un procédé de production d'un nouveau mutant protéique amélioré suscitant chez l'homme une faible réaction allergique comparée à celle des parents de ce mutant, et spécifiquement sur la neutralisation ou la réduction de l'allergénécité d'une protéine, en y introduisant, pour modifier ou remplacer un épitope, une séquence de subtilisine humaine.

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