Methods of treating chronic inflammatory diseases using a...

A - Human Necessities – 61 – K

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A61K 31/519 (2006.01) A61K 31/505 (2006.01) A61K 39/00 (2006.01) A61K 45/06 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2670288

The invention is based on the discovery that GM-CSF antagonists can be used for the treatment of chronic inflammatory disease, such as rheumatoid arthirtis. Accordingly, the invention provides methods of administering a GM-CSF antagonist, e.g., a GM-CSF antibody, and an anti-folate compounds, e.g., methotrexate, to a patient that has RA and pharmaceutical compositions comprising such antagonists.

La présente invention concerne une découverte selon laquelle les antagonistes du GM-CSF peuvent être utilisés pour le traitement d'une maladie inflammatoire chronique telle que la polyarthrite rhumatoïde. L'invention concerne donc des procédés d'administration d'un antagoniste du GM-CSF, par exemple un anticorps anti-GM-CSF, et d'un composé anti-folate, par exemple le méthotrexate, à un patient atteint de PR, ainsi que des compositions pharmaceutiques comprenant de tels antagonistes.

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