C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 241/44 (2006.01) A61K 31/495 (2006.01) A61K 51/04 (2006.01) C07D 241/38 (2006.01) C07D 241/52 (2006.01) C07D 241/54 (2006.01) C07D 487/04 (2006.01) C07D 491/04 (2006.01)
Patent
CA 2138026
Methods of treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglyemia and surgery, as well as treating neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease and Down's syndrome, treating or preventing the adverse consequences of hyperactivity of the excitatory amino acids, treating anxiety, chronic pain, convulsions, inducing anesthesia and psychosis by administering to an animal in need of such treatment a compound having high affinity for the glycine binding site, lacking PCP side effects and which crosses the blood brain barrier of the animal. Novel 1,4-dihydroquinoxaline- 2,3-diones having the Formula: Image or a tautomer thereof or a pharmaceutically acceptable salt thereof; wherein R1 is amino, hydroxylamino, acylamino, halo, haloalkyl, or nitro; R2 is hydrogen, amino, hydroxylamino, acylamino, halo, haloalkyl, or nitro; R3 is amino, hydroxylamino, acylamino, halo, or haloalkyl; and R4 is hydrogen, and pharmaceutical compositions thereof and highly soluble ammonium salts thereof are disclosed.
Keana John F. W.
Weber Eckard
Acting For And On Behalf Of The Oregon Health Sciences Univer State Of Oregon Acting By And Through The Oregon State Board Of
Gowling Lafleur Henderson Llp
Keana John F. W.
The Regents Of The University Of California
Weber Eckard
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