C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 311/06 (2006.01) A61K 31/20 (2006.01) A61K 31/23 (2006.01) A61P 27/06 (2006.01)
Patent
CA 2619890
The present invention provides wherein R1 is selected from the group consisting of C1-C10 alkoxy, OH and NR4R5; R2 is selected from the group consisting of C1-C10 alkyl and (CH2)nOH; R3 is selected from the group consisting of C1C10 alkyl, heteroaryl, e.g. thienyl, furanyl and pyridyl, phenyl, mono, -di-, tri-substituted phenyl and heteroaryl; R4 and R5 are independently selected from the group consisting of H, C1-C10 alkyl, C1-C10 alkyl hydroxyl; m is 0 or an integer from 1 to 3 and n is an integer of from 1 to 4. These compounds are useful in lowering intraocular pressure and/or treating glaucoma or providing neuroprotection to the eye of a human patient.
L'invention porte sur de nouvelles sulfonamides de formule (I) dans laquelle: R1 est sélectionné parmi C1-C10 alkoxy, OH et NR4R5; R2 est sélectionné parmi C1-C10 alkyle et (CH2)nOH; R3 est sélectionné parmi C1C10 alkyle, hétéroaryle, par exemple thiényle, furanyle, pyridyle, phényle, phényle mono, -di-, tri-substitué et hétéroaryle; R4 et R5 sont indépendamment sélectionnés parmi H, C1-C10 alkyle, C1-C10 alkyle hydroxyle; m est 0 ou un entier de 1 à 3 et n est un entier de 1 à 4. Ces composés peuvent servir à réduire la pression intraoculaire et/ou à traiter le glaucome ou à assurer une neuroprotection de l'oeil de l'homme.
Allergan Inc.
Gowling Lafleur Henderson Llp
LandOfFree
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