Novel antiangiogenic peptides

Details Novel antiangiogenic peptides Novel antiangiogenic peptides

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/00 (2006.01) A61K 38/16 (2006.01) A61P 35/00 (2006.01) C07K 14/81 (2006.01) C12N 15/63 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2367213

The present invention provides an antiangiogenic polypeptide having the amino acid sequence set forth in SEQ ID NO: 1 or a portion thereof which is effective to inhibit endothelial cell proliferation as determined by the capillary EC proliferation assay. Preferably, the portion has at least 50 % inhibition of bFGF-stimulated EC proliferation at 5 µg/ml, more preferably 75 % inhibition, most preferably 95 % inhibition.

L'invention concerne un peptide antiangiogénique présentant la séquence aminoacide spécifiée dans SEQ ID NO :1, ou une portion de celle-ci, efficace pour inhiber la prolifération de cellules endothéliales, comme déterminé par le test de prolifération capillaire EC. De préférence, la portion présente au moins 50 % d'inhibition de prolifération EC stimulé bFGF à 5 µg/ml, de préférence, 75 % d'inhibition, et mieux, 95 % d'inhibition.

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