Plant extracts and anti-cancer modalities involving the same

A - Human Necessities – 61 – K

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A61K 35/78 (1995.01)

Patent

CA 2320777

Compositions comprising a water/organic solvent extract of clover from which aromatic chromophore containing compounds including the isoflavones genistein, daidzein, formononetin and biochanin and/or their glycosides have been removed, said extract having anti-cancer activity against one or more of the cell lines HL60, K562, LNCaP or HT29, optionally in association with one or more pharmaceutically acceptable carriers, excipients, auxiliaries, and/or diluents are described as are processes for the production of these compositions. Methods of treatment, prophylaxis, amelioration or defence against cancer are also disclosed.

Composition constituées d'un extrait de trèfle à base d'eau/solvant organique, duquel on a enlevé les composés contenant le chromophore aromatique, comprenant des isoflavones, telles que la génistéine, la daidzénine, la formononétine et la biochanine et/ou leurs glycosides. Ledit extrait a une activité anti-cancéreuse contre une ou plusieurs des lignées cellulaires HLK60, K562, LNCaP ou HT29, éventuellement en association avec un ou plusieurs, excipients, auxiliaires et/ou diluants et vecteurs pharmaceutiquement acceptables. L'invention concerne aussi des procédés de production desdites compositions, des méthodes de traitement, d'atténuation du cancer, de prophylaxie ou de défense contre le cancer.

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