Acid labile drug compositions

Details Acid labile drug compositions Acid labile drug compositions

A - Human Necessities

61

K

A61K 9/48 (2006.01) A61K 9/00 (2006.01) A61K 9/14 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01) A61K 9/28 (2006.01) A61K 31/4184 (2006.01) A61K 31/4439 (2006.01) A61K 9/50 (2006.01)

Patent

CA 2511540

A composition and method of making a pharmaceutical dosage form containing an acid labile drug bound to an ion exchange resin is provided. The composition may be coated with a low acid content enteric coating. The binding of the acid labile drug to the exchange resin stabilizes the drug against acid degradation. The low acid content enteric coating controls the permeability of the enteric coating.

L'invention concerne une composition et un procédé permettant d'élaborer une forme dosifiée pharmaceutique contenant un médicament labile acide lié à une résine d'échange ionique. Cette composition peut être recouverte d'un revêtement gastro-résistant à faible contenu acide. La liaison du médicament labile acide avec la résine d'échange permet de stabiliser le médicament face à une dégradation acide. Ce revêtement gastro-résistant à faible contenu acide permet de réguler la perméabilité du revêtement gastro-résistant.

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