Human frezzled-like protein

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/00 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C07K 14/00 (2006.01) C07K 14/47 (2006.01) C12N 1/21 (2006.01) C12N 15/11 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2300390

The present invention relates to a novel HFLP protein which is a member of the frizzled family. In particular, isolated nucleic acid molecules are provided encoding the human HFLP protein. HFLP polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of HFLP activity. Also provided are diagnostic methods for detecting cell growth and differentiation-related disorders and therapeutic methods for treating cell growth and differentiation-related disorders.

L'invention concerne une nouvelle protéine HFLP qui est membre de la famille frizzled. Elle concerne, en particulier, des molécules isolées d'acide nucléique codant la protéine humaine HFLP. Elle concerne également des polypeptides HFLP, ainsi que des vecteurs, des cellules hôtes et des procédés de recombinaison servant à produire ces derniers. Elle concerne, de plus, des procédés de criblage servant à identifier des agonistes et des antagonistes de l'activité de HFLP. Elle concerne également des méthodes diagnostiques servant à détecter la croissance cellulaire et des troubles relatifs à la différenciation, et des méthodes thérapeutiques servant à traiter la croissance cellulaire et des troubles relatifs à la différenciation.

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