Ophthalmic compositions containing antibiotics and nsaids

Details Ophthalmic compositions containing antibiotics and nsaids Ophthalmic compositions containing antibiotics and nsaids

A - Human Necessities

61

K

A61K 31/535 (2006.01) A61K 31/40 (2006.01) A61P 27/02 (2006.01)

Patent

CA 2388297

Compositions including a quinolone component, such as ofloxacin, having fungistatic activity in the compositions, present in an amount effective as an antibiotic when the composition is placed in a mammalian eye, an NSAID component present in an amount to reduce inflammation or pain when the composition is placed in the eye, and a carrier component in an amount effective to act as a carrier for the quinolone component and NSAID component are provided. Methods of using the present compositions, for example, to resolve microbial infections and/or to reduce inflammation and/or pain in a mammalian eye are included within the scope of the present invention. Methods for treating corneal injuries are also included. In addition, methods for treating ocular infections, for example, corneal infections, are included.

L'invention concerne des compositions renfermant un composant quinolone, tel que l'ofloxacine, ayant une activité fongistatique dans les compositions, en quantités efficaces comme antibiotique lorsque la composition est placée dans l'oeil d'un mammifère, un composant AINS présent en quantités suffisantes pour réduire l'inflammation ou la douleur lorsque la composition est appliquée dans l'oeil, et un composant porteur en quantités suffisantes pour agir comme porteur du composant quinolone et du composant AINS. L'invention concerne également des procédés d'utilisation des compositions dans le but, par exemple, de stopper les infections microbiennes et/ou de réduire l'inflammation et/ou la douleur dans l'oeil d'un mammifère, ainsi que des méthodes de traitement de lésions cornéennes. L'invention concerne par ailleurs des méthodes de traitement d'infections oculaires, telles que des infections de la cornée.

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