Microemulsion preconcentrates comprising cyclosporins

A - Human Necessities – 61 – K

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Details

A61K 38/13 (2006.01) A61K 9/107 (2006.01) A61K 47/10 (2006.01) A61K 47/22 (2006.01)

Patent

CA 2240640

A pharmaceutical composition in the form of a microemulsion preconcentrate comprising a cyclosporin dissolved in a solvent system further comprising a hydrophobic component, a hydrophilic component, and a surfactant, wherein either the hydrophobic component is selected from tocol, tocopherols, tocotrienols, and derivatives thereof, or the hydrophilic component is selected from propylene carbonate or polyethylene glycol having an average molecular weight of less than 1000.

Composition pharmaceutique se présentant sous la forme d'un préconcentré en microémulsion contenant une cyclosporine dissoute dans un système de solvant comprenant en outre un constituant hydrophobe, un constituant hydrophile et un tensioactif, et dans lequel soit le constituant hydrophobe est choisi parmi le tocol, les tocophérols, les tocotriénols et des dérivés de ces derniers, soit le constituant hydrophile est choisi entre du carbonate de propylène et du polyéthylène glycol d'un poids moléculaire moyen inférieur à 1000.

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