N-oxides of heterocyclic compounds with tnf and pde-iv...

Details N-oxides of heterocyclic compounds with tnf and pde-iv... N-oxides of heterocyclic compounds with tnf and pde-iv...

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/47 (2006.01) A61P 11/06 (2006.01)

Patent

CA 2312430

N-oxides of formula (i) wherein R1 is CH3, CH2F, CHF2 or CF3; R2 is CH3 or CF3; R3 is F, Cl, Br, CN or CH3; and R4 is H, F, Cl, Br, CN or CH3; and pharmaceutically-acceptable salts thereof, are useful as therapeutic agents, e.g. for the treatment of inflammatory diseases.

La présente invention concerne des N-oxydes représentés par la formule (i) dans laquelle R¿1? est CH¿3?, CH¿2?F, CHF¿2? ou CF¿3?; R¿2? est CH¿3? ou CF¿3?; R¿3? est F, Cl, Br, CN ou CH¿3?; et R¿4? est H, F, Cl, Br, CN or CH¿3?; ainsi que des sels desdits composés acceptables au plans pharmaceutique, qui sont utiles comme agents thérapeutiques, notamment pour le traitement de maladies inflammatoires.

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