C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 305/00 (2006.01) C07D 407/00 (2006.01) C07D 493/00 (2006.01)
Patent
CA 2634453
The present invention is broadly directed to novel compounds useful for the synthesis of biologically active com- pounds. More particularly, the present embodiments disclosed herein relate to novel side chains, that when coupled to a taxane, are useful for the synthesis of pharmaceutically useful taxanes. Methods of forming the novel side chains and coupling them to hindered alcohols, namely taxanes resulting in useful esters are also disclosed. Various taxanes compounds are known to exhibit anti-tumor activity.
La présente invention concerne d'une façon générale de nouveaux composés utiles pour la synthèse de composés biologiquement actifs. Plus particulièrement, les modes de réalisation de la présente invention concernent de nouvelles chaînes latérales, lesquelles lorsqu'elles sont couplées à un taxane, sont utiles pour la synthèse de taxanes utiles du point de vue pharmaceutique. L'invention concerne également des procédés de formation des nouvelles chaînes latérales et de couplage de celles-ci à des alcools encombrés, à savoir des taxanes conduisant à des esters utiles. Différents composés taxanes sont connus comme présentant une activité antitumorale.
Henri John T.
Mcchesney James D.
Stemphoski Aaron Michael
Sumner Christian
Venkataraman Sylesh
Borden Ladner Gervais Llp
Tapestry Pharmaceuticals Inc.
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