C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/06 (2006.01) A61K 31/54 (2006.01) C07D 279/16 (2006.01)
Patent
CA 2058398
1,4-Benzothiazine-2-acetic acid derivatives represented by general formula (I) below: (see formula I) wherein R1 represents a group shown by general formula (II) or (III) (see formula II) (wherein R5 and R6, which may be the same or different, each represents hydrogen, a halogen, lower alkyl group, a lower alkoxyl group, trifluoromethyl or cyano; (see formula III) (wherein R7, R8, R9 and R10, which may be the same or different, each represents hydrogen, a halogen, a lower alkyl group, a lower alkoxyl group or trifluoromethyl); R2 and R3, which may be the same or different, each represents hydrogen, a halogen, a lower alkyl group, a lower alkoxyl group, a lower alkylthio group, trifuloromethyl or trifluoromethoxy; R4 represents carboxyl which may be optionally be esterified; and X represents oxygen or sulfur; and processes for production thereof, as well as a composition for the treatment of diabetic complications and an aldose reductase inhibitor comprising the same.
Aotsuka Tomoji
Hosono Hiroshi
Kobayashi Fujio
Kurihara Toshio
Matsui Tetsuo
Sapporo Breweries Limited
Senju Pharmaceutical Co. Ltd.
Smart & Biggar
Welfide Corporation
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