Solid dispersions of opioid antagonists

Details Solid dispersions of opioid antagonists Solid dispersions of opioid antagonists

A - Human Necessities

61

K

A61K 31/445 (2006.01) A61P 1/08 (2006.01) A61P 1/10 (2006.01)

Patent

CA 2628781

Solid dispersions of stable, amorphous opioid antagonists, particularly [[2(S)- [[4(R)- (3 -hydroxyphenyl)-3 (i),4-dimethyl-piperidinyl]methyl] - 1 -oxo-3 - phenylpropyl] amino] acetic acid, with improved water solubility and bioavailability are disclosed. Also disclosed are methods of preventing or treating a side effect associated with an opioid. In addition, methods of treating or preventing pain, ileus, and opioid bowel dysfunction are disclosed.

cette invention concerne des dispersions solides d'antagonistes opioïdes amorphes stables, en particulier l'acide [[2(S)-[[4(R)- (3 -hydroxyphényl)-3 (i),4-diméthyl-pipéridinyl]méthyl] - 1 -oxo-3 -phénylpropyl] amino] acétique caractérisées par une hydrosolubilité et un biodisponibilité améliorées. L'invention concerne également des méthodes de prévention ou de traitement d'effet secondaire associé à un opioïde. Sont également décrites des méthodes de traitement ou de prévention de la douleur, d'iléus et de dysfonctionnement intestinal dus à un opioïde.

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