A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/00 (2006.01) A61K 31/16 (2006.01) A61K 31/365 (2006.01) A61K 31/573 (2006.01) A61K 38/00 (2006.01) A61K 38/13 (2006.01) A61K 39/395 (2006.01) A61K 45/06 (2006.01) A61P 37/06 (2006.01)
Patent
CA 2644020
Methods of prolonging survival of allotransplanted cells, tissues or organs are presented. These methods are directed to administering to the allograft recipient an inhibitor of complement activity together with one or more immunosuppressants and/or immunosuppressive methods. The inhibitor of complement activity is administered chronically. These methods have been determined to aid in preventing chronic rejection of allografts. These methods can additionally be used in cases in which the recipient has been presensitized to the allograft or in which there is an ABO mismatch between the allograft and the recipient.
La présente invention concerne des procédés de prolongation de la survie de cellules, de tissus ou d'organes allogreffés. Ces procédés sont destinés à administrer au receveur de l'allogreffon un inhibiteur d'activité complémentaire ainsi qu'un ou plusieurs immunosuppresseurs et/ou procédés d'immunosuppression. L'inhibiteur d'activité complémentaire est administré de manière chronique. Ces procédés s'avèrent efficaces pour prévenir le rejet chronique des allogreffons. En outre, ces procédés peuvent être appliqués lorsque le receveur a été présensibilisé à l'allogreffon ou en cas d'incompatibilité ABO entre l'allogreffon et le receveur.
Rother Russell P.
Wang Hao
Zhong Zhen
Alexion Pharmaceuticals Inc.
Mcfadden Fincham
LandOfFree
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