C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) A61K 39/395 (2006.01) A61K 39/40 (2006.01) C07K 14/40 (2006.01) C07K 16/00 (2006.01) C07K 16/14 (2006.01) G01N 33/53 (2006.01) G01N 33/569 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2482764
An isolated surface protein known as mp58 is provided from the yeast candida albicans which has specific active peptide and carbohydrate regions and immunogenic epitopes therein and which elicits strong antibody responses during candidiasis. Antibodies raised from mp58 and the immunogenic regions and epitopes therein are also provided which can recognize the protein and its active regions and epitopes. The protein and antibodies of the present invention will thus be useful in methods of diagnosing, monitoring, treating or preventing infection of C. albicans and other yeast, and can also provide the basis for the development of immunity-based prophylactic, therapeutic and diagnostic techniques for the identification and management of disease conditions such as candidiasis.
L'invention concerne une protéine de surface isolée connue en tant que mp58 et issue de la levure <i>candida albicans</i> qui a des régions de peptide actif et de carbohydrate spécifiques et les épitopes immunogènes contenus dans ces régions et qui génère de fortes réponses anticorps pendant la candidose. L'invention concerne également des anticorps issus de la mp58 et les régions immunogènes et les épitopes contenus dedans, pouvant reconnaître la protéine, ses régions actives et les épitopes. La protéine et les anticorps de la présente invention seront ainsi utiles dans les procédés de diagnostic, de surveillance, de traitement ou de prévention de l'infection de <i>C.</i> <i>albicans</i> et autres levures, et peut également être la base du développement des techniques prophylactiques, thérapeutiques et de diagnostic basées sur l'immunité et destinées à l'identification et à la gestion d'états pathologiques tels que la candidiose.
Board Of Regents Of The University Of Texas System
Mccarthy Tetrault Llp
LandOfFree
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