C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/80 (2006.01) A61K 38/21 (2006.01) C07K 14/47 (2006.01) C07K 14/715 (2006.01) C07K 16/28 (2006.01) C12N 9/10 (2006.01) C12N 15/63 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2276111
Novel proteins IR1B1 and IR1B4 have been isolated which bind to the type I IFN receptor IFNAR1 and function in the cellular response to IFNs. DNA encoding such proteins in either the sense or anti-sense orientation can be administered to either enhance or inhibit the cellular response to IFNs. Antibodies to the proteins can be used for isolation of the new protein or for immunodetection thereof.
L'invention porte sur de nouvelles protéines IR1B1 et IR1B4 qui ont été isolées. Ces protéines se lient au récepteur IFNAR1 d'IFN de type I et interviennent dans la réponse cellulaire aux IFNs. De l'ADN à orientation sens ou anti-sens codant pour ces protéines peut être administré pour augmenter ou inhiber la réponse cellulaire aux IFNs. Les anticorps de ces protéines peuvent être utilisés pour l'isolation des nouvelles protéine ou pour l'immunodétection de ces dernières.
Abramovitch Carolina
Chebath Judith E.
Revel Michel
Gowling Lafleur Henderson Llp
Yeda Research And Development Co. Ltd.
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