Pyrazolothiazolopyrimidine derivatives

Details Pyrazolothiazolopyrimidine derivatives Pyrazolothiazolopyrimidine derivatives

C - Chemistry, Metallurgy

07

D

C07D 513/14 (2006.01) A61K 31/505 (2006.01) A61K 31/54 (2006.01) A61K 31/55 (2006.01)

Patent

CA 2103678

- 66 - The present invention relates to pyrazolothiazolopyrim- idine derivatives represented by the following Formula (I): Image (I) in which R1 represents hydrogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, halogen or -NR3R4 (in which R3 and R4 represent independently hydrogen, lower alkyl, lower alkanoyl or aroyl); when R2 is a substituent on the 1-position, X represents N or CH, and R2 represents hydrogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl or lower alkoxycarbonyl; when R2 is a substituent on the 2-position, X represents N, and R2 represents -CR5R6R7 (in which R5 represents substituted or unsubstituted lower alkyl; and R6 and R7 represent independently hydrogen or lower alkyl), substituted or unsubstituted aryl, substituted or unsubstituted aralkyl or lower alkoxycarbonyl; Y represents O or S; Q represents -CR8R9CR10R11-(CH2)n- or -CR8=R9-(CH2)n- (in which R8, R9, R10 and R11 represent independently hydrogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl or lower alkoxycarbonyl; and n is an integer of 0 to 2) and pharmaceutically acceptable salts thereof which are useful as anti-inflammatory, analgesic, immunomodulatory and anti- ulcer agents.

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