Transforming growth factor beta crystals

Details Transforming growth factor beta crystals Transforming growth factor beta crystals

C - Chemistry, Metallurgy

07

K

C07K 14/495 (2006.01) A61K 38/18 (2006.01)

Patent

CA 2225963

The invention concerns TGF-.beta. in a crystalline form which shows no adsorption or less adsorption to the wall of vials than the soluted TGF-.beta. and which is more stable towards oxidative agent tahn the soluted form. TGF-.beta. crystals of the invention can be used for structure determination and for drug design and for the production of a slow release pharmaceutical preparation.

Cette invention concerne le TGF- beta sous forme cristalline qui ne présente pas du tout d'adsorption ou moins d'adsorption sur la paroi des flacons que le TGF- beta en solution et qui est plus stable aux agents oxydants que la forme en solution. On peut utiliser les cristaux de TGF- beta pour déterminer des structures et concevoir des médicaments ainsi que pour produire une préparation pharmaceutique à libération lente.

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