Secreted proteins and polynucleotides encoding them

Details Secreted proteins and polynucleotides encoding them Secreted proteins and polynucleotides encoding them

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 38/48 (2006.01) C07K 14/47 (2006.01) C07K 14/52 (2006.01) C07K 14/705 (2006.01) C12N 9/64 (2006.01) C12N 15/57 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2251934

The invention provides 5 clones G 52-24, H 1075-1, J 59-41, H 83-22, J 143-1 isolated from a human PBMC cDNA library and one clone M 97-2 from a human glioblastoma cell line T 98 G cDNA library using a method of screening for cDNAs encoding secreted proteins. Determination of the nucleotide sequences and of the deduced amino acid sequences.

L'invention a trait à cinq clones G52-24, H1075-1, J59-41, H83-22 et J143-1, provenant d'une banque d'ADNc d'hématocrites mononucléaires humains périphériques (PBMC), ainsi qu'à un clone M97-2 provenant d'une banque d'ADNc T98G (lignée cellulaire d'un glioblastome humain). Ces clones ont été isolés par criblage d'ADNc codant des protéines sécrétées. L'invention a également trait à une détermination de séquences nucléotidiques ainsi qu'à des séquences d'acides aminés déduites.

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