Insulin-like polypeptide and uses therefor

Details Insulin-like polypeptide and uses therefor Insulin-like polypeptide and uses therefor

C - Chemistry, Metallurgy

12

N

C12N 15/16 (2006.01) C07K 14/47 (2006.01) C07K 14/62 (2006.01) C07K 14/64 (2006.01) C07K 14/65 (2006.01) C07K 16/26 (2006.01) C07K 19/00 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01) G01N 33/74 (2006.01)

Patent

CA 2304102

The present invention provides nucleotide and amino acid sequences that identify and encode a novel expressed insulin-like polypeptide (ILP) from, for example, colon and uterine cells. The present invention also provides for antisense molecules to the nucleotide sequences which encode ILP, expression vectors for the production of purified ILP, antibodies capable of binding specifically to ILP, hybridization probes or oligonucleotides for the detection of ILP-encoding nucleic acid sequences, genetically engineered host cells for the expression of ILP, diagnostic tests for insulin-like activation based on ILP-encoding nucleic acid molecules and antibodies capable of binding specifically to the protein.

La présente invention concerne des séquences nucléotidiques et d'acides aminés destinées à identifier et à coder un nouveau polypeptide exprimé de type insuline (ILP), exprimé par exemple à partir de cellules du colon ou de l'utérus. La présente invention concerne également les molécules antisens desdites séquences nucléotidiques codant l'ILP, des vecteurs d'expression permettant de produire un ILP purifié, des anticorps capables de se fixer spécifiquement à cet ILP, des sondes d'hybridation ou des oligonucléotides conçus pour détecter les séquences d'acide nucléique codant l'ILP, des cellules hôtes génétiquement manipulées permettant d'exprimer l'ILP, des tests destinés à diagnostiquer l'activation de type insuline en fonction des molécules d'acide nucléique codant l'ILP, et des anticorps capables de se fixer spécifiquement à la protéine.

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