C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/00 (2006.01) C07F 9/40 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2406169
The invention relates to PNA derivatives that carry one or more phosphoryl groups at the C terminus or at the C and N terminus of the PNA backbone, said phosphoryl groups optionally carrying one or more marker groups, or groups for cross-linking, or groups that promote the intracellular uptake, or groups that improve the binding affinity of the PNA derivative to nucleic acids. The invention further relates to a method for producing the above PNA derivatives and to the use thereof as a medicament or diagnostic agent.
L'invention concerne des dérivés d'acide nucléique polyamide qui portent, en position terminale C ou C et N du tronc d'acide nucléique polyamide, un ou plusieurs restes phosphoryle qui portent quant à eux, éventuellement un ou plusieurs groupes marqueurs ou des groupes de réticulation transversale ou des groupes favorisant l'absorption intracellulaire ou des groupes qui augmentent l'affinité de liaison du dérivé d'ADN pour des acides nucléiques. L'invention concerne par ailleurs un procédé permettant de préparer les dérivés d'acide nucléique polyamide mentionnés ci-dessus, ainsi que leur utilisation comme médicament ou agent diagnostique.
Breipohl Gerhard
Uhlmann Eugen
Will David William
Aventis Pharma Deutschland Gmbh
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Sanofi-Aventis Deutschland Gmbh
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