Methods of inhibiting neuronal damage

Details Methods of inhibiting neuronal damage Methods of inhibiting neuronal damage

A - Human Necessities

61

K

A61K 31/38 (2006.01) A61K 31/40 (2006.01) A61K 31/4025 (2006.01) A61K 31/445 (2006.01) A61K 31/4535 (2006.01) A61K 31/53 (2006.01) A61K 31/55 (2006.01)

Patent

CA 2198015

A method for inhibiting neuronal damage due to hypoglycemia comprising administering to a human in need thereof an effective amount of a compound having formula (I) wherein R1 and R3 are independently hydrogen, -CH3, (a), or (b), wherein Ar is optionally substituted phenyl; R2 is selected from the group consisting of pyrrolidine, hexamethyleneimino, and piperidino; or a pharmaceutically acceptable salt or solvate thereof.

Procédé enrayant la survenue de lésions neuronales due à l'hypoglycémie consiste à administrer à un être humain le nécessitant une quantité efficace d'un composant représenté par la formule générale (I) ou de l'un de ses sels ou solvates pharmaceutiquement acceptables. Dans cette formule générale "R?1¿" et "R?3¿" sont indépendamment hydrogène, -CH¿3?, (a), ou (b), où "Ar" est phényle éventuellement substitué. "R?2¿" appartient au groupe formé par les pyrrolidine, hexaméthylèneimino et pipéridino.

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