Method for identifying binding partners with...

Details Method for identifying binding partners with... Method for identifying binding partners with...

G - Physics

01

N

G01N 33/68 (2006.01) C12Q 1/68 (2006.01) G01N 33/543 (2006.01) H01J 49/00 (2006.01) H01J 49/04 (2006.01)

Patent

CA 2386607

Disclosed is a method for identifying binding partners with position-specific arrays by means of mass spectrometry. A position-specific ligat array is produced on a carrier material by means of small volumes which are position- specifically mounted and belong to reaction partners. At least two successive reactions are carried out gradually. The position-specific ligat array that is fixed to the carrier material is incubated with a mixture of ligands. Ligands that are not bound to the ligat array are subsequently removed and the ligand/s that is/are bound to the ligat array are further characterised by means of mass spectrometry.

L'invention concerne un procédé pour l'identification par spectrométrie de masse de partenaires de liaison à l'aide de jeux ordonnés d'échantillons. Dans le procédé selon l'invention, on produit un jeu ordonné d'échantillons de ligature sur un matériau support au moyen de petits volumes de réactifs appliqués de manière ordonnée en exécutant progressivement au moins deux réactions consécutives, on fait incuber le jeu ordonné d'échantillons de ligature fixé sur le matériau support avec un mélange de ligands, on supprime ensuite les ligands non liés au jeu d'échantillons de ligature et on poursuit la caractérisation du ou des ligands liés au jeu d'échantillons de ligature par spectrométrie de masse.

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