Method and composition for preventing, reducing and...

A - Human Necessities – 61 – K

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A61K 31/74 (2006.01)

Patent

CA 2522043

Methods and compositions are provided for preventing, reducing and reversing ischemic neuronal damage related to congenital and acquired ophthalmologic conditions such as macular degeneration, retinitis pigmentosa, optic neuritis, neuroretinitis, Lebers congenital amaurosis, Stargardts disease, Parkinson's disease, diabetic retinopathy, idiopathic senile vision loss, uveitis, edema and ocular surgery. An amount of an acetylcholine esterase inhibitor containing composition is administered to the eye of a mammal, either topically or via a controlled-release drug delivery system.

L'invention concerne des procédés et des compositions pour prévenir, réduire et inverser les lésions neuronales ischémiques liées à des états ophtalmologiques congénitaux ou acquis tels quel la dégénérescence maculaire, retinitis pigmentosa, la névrite optique, la neurorétinite, l'amaurose congénitale de Lebers, la maladie de Stargardts, la maladie de Parkinson, la rétinopathie diabétique, la perte de vision sénile idiopathique, l'uvéite, l'oedème et la chirurgie oculaire. Une quantité nécessaire d'une composition contenant un inhibiteur d'estérase d'acétylcholine est appliquée à l'oeil d'un mammifère, de façon topique ou au moyen d'un système d'administration de médicaments à libération contrôlée.

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