Amino and nitro containing tricyclic compounds useful as...

Details Amino and nitro containing tricyclic compounds useful as... Amino and nitro containing tricyclic compounds useful as...

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/55 (2006.01) C07D 487/04 (2006.01) C07D 498/04 (2006.01) C07D 513/04 (2006.01) C07K 5/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2057786

The present invention relates to compounds of the formula (see formula I) wherein A is methylene, oxygen, sulfur or N-B wherein B is R1 or COR2 wherein R1 is hydrogen, a C1-C4 alkyl or an Ar-Z- group wherein Ar is aryl and Z is a C0-C4 alkyl and R2 is a -CF3, a C1-C10 alkyl or an Ar-Z group; R is hydrogen ar a C1-C4 alkyl; and X and Y are each independently hydrogen, nitro or amino, with the proviso that when X is nitro or amino, Y must be hydrogen, and when Y is nitro or amino, X must be hydrogen; and pharmaceutically acceptable salts thereof, which are inhibitors of Angiotensin Converting Enzyme.

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